HCID 86659298, compound → HCID 58515949, compound

HRID 717848Notes

Reaction equation

HRID 717848 reaction equation
[Cl:1][C:2]1[C:3]2[N:4]([C:22]([CH3:25])=[N:23][CH:24]=2)[C:5]([C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[CH:15]=2)=[C:6]([C:8](N(OC)C)=[O:9])[CH:7]=1.Cl[Mg][CH2:28][CH3:29]>>[Cl:1][C:2]1[C:3]2[N:4]([C:22]([CH3:25])=[N:23][CH:24]=2)[C:5]([C:14]2[CH:15]=[C:16]([F:21])[CH:17]=[C:18]([F:20])[CH:19]=2)=[C:6]([C:8](=[O:9])[CH2:28][CH3:29])[CH:7]=1

Participants

3

Reactant 2

HCID 86659298HCID 86659298, compoundHCID 178461633HCID 178461633, compound

Product 1

HCID 58515949HCID 58515949, compoundYield 39%

Procedure

The desired compound was prepared by the procedure of Example 1, step J using 8-chloro-5-(3,5-difluorophenyl)-N-methoxy-N,3-dimethylimidazo[1,5-a]pyridine-6-carboxamide and chloro(ethyl)magnesium as the starting materials in 39% yield. LCMS calculated for C17H14ClF2N2O (M+H)+: m/z=335.1. found: 334.9.

Sources & evidence

ORD record
ord-35c02362d45f4ede9274e59c77c1f81c
Source dataset
uspto-grants-2015_11
Patent number
US09193721B2

Reaction notes

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