Diisopropylethylamine → HCID 58515996, compound

Participants

Reaction Steps

A solution of 1-[5-(4-acetylpiperazin-1-yl)-8-bromoimidazo[1,5-a]pyridin-6-yl]ethanamine bis(trifluoroacetate) (67 mg, 0.11 mmol), 6-bromo-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (48 mg, 0.17 mmol), and N,N-diisopropylethylamine (98 mL, 0.56 mmol) in ethanol (0.87 mL) was heated at 95° C. overnight. Purification via preparative HPLC on a C-18 column eluting acetonitrile: water gradient buffered with ammonia to pH 10 gave the desired product (36 mg, 56%). LCMS for C25H31BrN9O2 (M+H)+: m/z=568.2, 570.2. Found: 568.0, 570.0.

Provenance & Evidence