Triethyl(methoxycarbonylsulfamoyl)aminium → 2-Neopentyl-5-(4-nitrophenyl)-1,3,4-oxadiazole

HRID 717987Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 717987
[CH3:1][C:2]([CH3:20])([CH3:19])[CH2:3][C:4]([NH:6][NH:7][C:8](=[O:18])[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)=O.C([N+](CC)(CC)S(NC(=O)OC)(=O)=O)C>O1CCCC1>[CH2:3]([C:4]1[O:18][C:8]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[N:7][N:6]=1)[C:2]([CH3:20])([CH3:19])[CH3:1]

Komponenten

4

Edukt 2

HCID 2724995Triethyl(methoxycarbonylsulfamoyl)aminiumHCID 4628581N'-(3,3-dimethylbutanoyl)-4-nitrobenzohydrazide

Produkt 1

HCID 867020152-Neopentyl-5-(4-nitrophenyl)-1,3,4-oxadiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of N′-(3,3-dimethylbutanoyl)-4-nitrobenzohydrazide (0.556 g, 1.991 mmol) and methyl N-(triethylammoniumsulfonyl)carbamate (0.572 g, 2.389 mmol) in tetrahydrofuran (10 ml) was heated to 120° C. in a microwave for 45 minutes. The crude reaction mixture was concentrated and purified by normal phase chromatography to give the title compound.

Aufarbeitung

  1. customThe crude reaction mixture
  2. concentrationwas concentrated
  3. custompurified by normal phase chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3c6bd70555a84d25aa4f010817244a7d
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09193723B2

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