HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Oxabicyclo[3.1.0]hexane → HCID 86713721, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Oxabicyclo[3.1.0]hexane | HCID 9244 | — |
| Reactant | 3,5-Difluorobenzyl bromide | HCID 518896 | — |
| Product | HCID 86713721 | HCID 86713721 | — |
Reaction Steps
Reaction of the Grignard reagent prepared from 1-(bromomethyl)-3,5-difluorobenzene with 6-oxabicyclo[3.1.0]hexane gave trans-2-(3,5-difluorobenzyl)cyclopentanol. Conversion to the mesylate, followed by displacement with sodium azide and reduction with triphenylphosphine afforded cis-2-(3,5-difluorobenzyl)cyclopentanamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193726B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-44a7f9a74d8a4879a3929e5da3be2292 |
| Source note | uspto-grants-2015_11 |