HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Formylfuran-2-boronic acid → {cis-5-[4-(Pentafluoro-lambda6-sulfanyl)phenyl]tetrahydrofuran-2-yl}methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Formylfuran-2-boronic acid | HCID 2734355 | — |
| Reactant | 1-Bromo-4-(pentafluoro-lambda6-sulfanyl)benzene | HCID 2779194 | — |
| Catalyst | Ruthenium dioxide hydrate | HCID 16211523 | — |
| Product | {cis-5-[4-(Pentafluoro-lambda6-sulfanyl)phenyl]tetrahydrofuran-2-yl}methanol | HCID 86713723 | — |
Reaction Steps
The requisite {cis-5-[4-(pentafluoro-λ6-sulfanyl)phenyl]tetrahydrofuran-2-yl}methanol was prepared via Suzuki reaction of (5-formylfuran-2-yl)boronic acid with 1-bromo-4-(pentafluoro-λ6-sulfanyl)benzene, followed by hydrogenation in the presence of ruthenium(IV) oxide hydrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193726B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-2efb9af4a4a84bc493dd27506deeda33 |
| Source note | uspto-grants-2015_11 |