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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 718028Generated: October 30, 2026

5-Bromofuran-2-carbaldehyde → HCID 86713730, compound

https://huagongshe.com/reaction/718028

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromofuran-2-carbaldehydeHCID 600328—
Reactant2-[4-(1,1-Difluoroethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 46835487—
CatalystRuthenium dioxide hydrateHCID 16211523—
ProductHCID 86713730HCID 86713730—

Reaction Steps

The requisite {cis-5-[4-(1,1-difluoroethyl)phenyl]tetrahydrofuran-2-yl}methanol was prepared via Suzuki reaction of 5-bromofuran-2-carbaldehyde with 2-[4-(1,1-difluoroethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, followed by hydrogenation in the presence of ruthenium(IV) oxide hydrate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09193726B2
Source datasetuspto-grants-2015_11
ORD IDord-6aaf6eeea45c4a8e8c2a1ebdb03072a4
Source noteuspto-grants-2015_11