Diphenyl Ether → 8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Participants

Reaction Conditions

Reaction Steps

The 2-(2-amino-4-chlorophenylamino)benzoic acid (2.00 g, 7.63 mmol) was mixed with diphenyl ether (5 mL). The reaction mixture was stirred at 175° C. for 2 hours. The mixture was cooled down to room temperature and put directly to the column eluting with 10% to 50% ethyl acetate in hexanes to afford the title compound 9 (1.42 g, 76%) as a purple solid.

Provenance & Evidence