Bicarbonate Ion → HCID 67007739, compound

Participants

Reaction Steps

A stirring solution of title compound 206 (0.5 g, 1.914 mmol) and ethyl 4-fluorobenzoate (0.421 ml, 2.87 mmol) in DMSO (19.14 mL) was stirred at 140° C. overnight. The mixture was cooled down and poured over a diluted aqueous solution of bicarbonate and extracted with ethyl acetate (twice). The combined organic extracts were washed with brine, dried over Na2SO4, filtered and evaporated. The crude was purified by flash chromatography: 0% to 60% ethyl acetate in hexanes over 20 min on 20 g SiO2 to afford title compound 207 (0.33 g, 51%) as beige oil. LRMS: (calc) 336.18. (found) 337.4 (MH)+.

Provenance & Evidence