Glycine ethyl ester → (Z)-8-bromo-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one

Participants

Reaction Steps

(2-Amino-4-bromophenyl)(phenyl)methanone (1.75 g, 10 mmol), ethyl 2-aminoacetate (2.23 g, 16 mmol) and pyridine (40 mL) were stirred together at 80° C. for about 3 days. The pyridine was evaporated and the residue was triturated in 5% methanol in ethyl acetate to afford title compound 354 (1.6 g, 51%) as a yellow solid.

Provenance & Evidence