HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl bromide → 10-(prop-2-ynyl)dibenzo[b,f][1,4]oxazepin-11(10H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | O-(o-Aminophenoxy)benzoic acid lactam | HCID 72374 | — |
| Reactant | 7-chloro-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one | HCID 21539232 | — |
| Product | 10-(prop-2-ynyl)dibenzo[b,f][1,4]oxazepin-11(10H)-one | HCID 59783448 | — |
Reaction Steps
Using Procedure H-3 (Table 5) with dibenzo[b,f][1,4]oxazepin-11(10H)-one and 3-bromoprop-1-yne the title compound 85 was obtained (1.58 g, 89%) as an off-white solid. 1H NMR (DMSO-d6) δ (ppm): 7.76 (ddd, J=7.5, 1.7, 0.4 Hz, 1H), 7.65 (dd, J=8.0, 1.7 Hz, 1H), 7.61 (ddd, J=8.2, 7.2, 1.8 Hz, 1H), 7.41 (dd, J=7.8, 1.6 Hz, 1H), 7.37 (ddd, J=8.2, 1.0, 0.4 Hz, 1H), 7.34-7.24 (m, 3H), 4.83 (d, J=2.3 Hz, 2H), 3.31 (t, J=2.3 Hz, 1H). MS (m/z): 250.0 (M+H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193749B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-f5ea69a7086b43228a74abd3165720dc |
| Source note | uspto-grants-2015_11 |