Hydrazine → 2-Chloro-3-hydrazinopyrazine

Temperature

80 °C

2,3-Dichloropyrazine (2 g, 13.42 mmol), hydrazine (1.324 g, 26.8 mmol) and ethanol (40 ml) were combined and the reaction mixture was stirred at 80° C. for 1.5 h. The mixture was cooled to room temperature and the yellow flakes were filtered off. The solid was washed with a small amount of water and dried. The mother liquor was concentrated to afford a yellow solid triturated with a small amount of water and dried. The 2 solids were combined to afford title product 471 (1.15 g, 59%) as yellow solid. MS (m/z): 145.0 (M+H).

1. temperatureThe mixture was cooled to room temperature
2. filtrationthe yellow flakes were filtered off
3. washThe solid was washed with a small amount of water
4. customdried
5. concentrationThe mother liquor was concentrated
6. customto afford a yellow solid
7. customtriturated with a small amount of water
8. customdried

ORD record

ord-76ea126616764da59567f2e0f63e9a47

Source dataset

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09193749B2