(3R,4S,5R,6R)-3,4,5-Tris-trimethylsilanyloxy-6-trimethylsilanyloxymethyl-tetrahydro-pyran-2-on → delta-Gluconolactone

Participants

Reaction Conditions

Reaction Steps

A 5 L glass-lined reactor was charged with (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-((trimethylsilyloxy)methyl)tetrahydro-2H-pyran-2-one (1.52 kg) and n-heptane (1.63 kg) and stirred for 10 min under nitrogen sparging. After sparging, the mixture was cooled to −30 to −20° C. under nitrogen atmosphere, stirred for 30 minutes, and then added to a cooled addition funnel.

Provenance & Evidence