HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 71821Generated: October 28, 2026
Trimethylsilyldiazomethane → 1-(4-Bromonaphthalen-1-yl)-2-diazoethanone
https://huagongshe.com/reaction/71821
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 4-Bromonaphthalene-1-carbonyl chloride | HCID 14700024 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-Bromonaphthalen-1-yl)-2-diazoethanone | HCID 72337901 | — |
Reaction Steps
4-Bromo-naphthalene-1-carbonyl chloride (13.8 g) was dissolved in dichloromethane (130 mL) and cooled to 0° C. TMS diazomethane solution (40 mL, 2 M in DCM) was added, and ice bath was removed. Reaction mixture was stirred for 18 hours and evaporated under vacuum, giving 1-(4-bromonaphthalen-1-yl)-2-diazoethanone (13.8 g, crude) as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08822430B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-98e0ad8424274c1bbf14d8f665493ddd |
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| Source note | uspto-grants-2014_09 |
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