HRID718273

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74649

Acetic acid, (4-methoxyphenoxy)-

C9H10O4

结构：COc1ccc(CCc2nc3c(N4CCNCC4)nc(N)nc3s2)cc1OC

HCID66758068

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(OCC(=O)N2CCN(c3nc(N)nc4sc(CCc5ccc(OC)c(OC)c5)nc34)CC2)cc1

HCID66758673

未命名化合物

收率 71%

PROCEDURE

实验过程

This compound was prepared from 2-(3,4-dimethoxyphenethyl)-7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidin-5-amine using 4-methoxyphenoxyacetic acid in a yield of 71%, according to the procedure for the synthesis of example 50.

WORKUP

后处理

customaccording to the procedure for the synthesis of example 50

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1953ae6ea486484a95b528ab7c34bdf8
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09193741B2
来源说明: uspto-grants-2015_11

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[CH2:6][CH2:7][C:8]1[S:9][C:10]2[N:11]=[C:12]([NH2:23])[N:13]=[C:14]([N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[C:15]=2[N:16]=1.[CH3:29][O:30][C:31]1[CH:41]=[CH:40][C:34]([O:35][CH2:36][C:37](O)=[O:38])=[CH:33][CH:32]=1>>[NH2:23][C:12]1[N:13]=[C:14]([N:17]2[CH2:18][CH2:19][N:20]([C:37](=[O:38])[CH2:36][O:35][C:34]3[CH:40]=[CH:41][C:31]([O:30][CH3:29])=[CH:32][CH:33]=3)[CH2:21][CH2:22]2)[C:15]2[N:16]=[C:8]([CH2:7][CH2:6][C:5]3[CH:24]=[CH:25][C:26]([O:27][CH3:28])=[C:3]([O:2][CH3:1])[CH:4]=3)[S:9][C:10]=2[N:11]=1