4-Cyanophenyl isocyanate → HCID 66757676, compound

HRID 718284Notes

Reaction equation

HRID 718284 reaction equation
[N:1]1([C:7]2[C:8]3[N:16]=[C:15]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[S:14][C:9]=3[N:10]=[C:11]([NH2:13])[N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:23]([C:25]1[CH:30]=[CH:29][C:28]([N:31]=[C:32]=[O:33])=[CH:27][CH:26]=1)#[N:24]>>[NH2:13][C:11]1[N:12]=[C:7]([N:1]2[CH2:6][CH2:5][N:4]([C:32]([NH:31][C:28]3[CH:29]=[CH:30][C:25]([C:23]#[N:24])=[CH:26][CH:27]=3)=[O:33])[CH2:3][CH2:2]2)[C:8]2[N:16]=[C:15]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[S:14][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 1703804-Cyanophenyl isocyanateHCID 509420567-(Piperazin-1-yl)-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-5-amine

Product 1

HCID 66757676HCID 66757676, compoundYield 53%

Procedure

This compound was prepared from 7-(piperazin-1-yl)-2-(pyridin-3-yl)thiazolo[5,4-d]pyrimidin-5-amine using 4-cyanophenyl isocyanate in a yield of 53%, according to the procedure for the synthesis of example 42.

Workup

  1. customaccording to the procedure for the synthesis of example 42

Sources & evidence

ORD record
ord-9f812800ac4f4ab0a8fa843215721fe5
Source dataset
uspto-grants-2015_11
Patent number
US09193741B2

Reaction notes

Loading…