3-(4-Bromophenyl)propionic acid → HCID 66758492, compound

HRID 718290Notes

Reaction equation

HRID 718290 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[C:5]([NH2:21])=[C:4]([SH:22])[N:3]=1.[Br:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][C:32](O)=O)=[CH:26][CH:25]=1>>[Br:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][C:32]2[S:22][C:4]3[N:3]=[C:2]([NH2:1])[N:7]=[C:6]([N:8]4[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]4)[C:5]=3[N:21]=2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 27356093-(4-Bromophenyl)propionic acidHCID 178452268HCID 178452268, compound

Product 1

HCID 66758492HCID 66758492, compoundYield 70%

Procedure

This compound was synthesized from tert-butyl 4-(2,5-diamino-6-mercaptopyrimidin-4-yl)piperazine-1-carboxylate using 3-(4-bromophenyl)propionic acid, yielding the title compound in 70% yield.

Sources & evidence

ORD record
ord-45acda305c0c40139d2e6e16245f7407
Source dataset
uspto-grants-2015_11
Patent number
US09193741B2

Reaction notes

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