4-Methylbenzoyl Chloride → HCID 50942148, compound

HRID 718292Notes

Reaction equation

HRID 718292 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[C:5]([NH2:21])=[C:4]([SH:22])[N:3]=1.[C:23]1([CH3:32])[CH:28]=[CH:27][C:26]([C:29](Cl)=O)=[CH:25][CH:24]=1>>[N:8]1([C:6]2[C:5]3[N:21]=[C:32]([C:23]4[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=4)[S:22][C:4]=3[N:3]=[C:2]([NH2:1])[N:7]=2)[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 134054-Methylbenzoyl ChlorideHCID 178452268HCID 178452268, compound

Product 1

HCID 50942148HCID 50942148, compoundYield 80%

Procedure

This compound was synthesized from tert-butyl 4-(2,5-diamino-6-mercaptopyrimidin-4-yl)piperazine-1-carboxylate using p-toluoyl chloride, yielding the title compound in 80% yield.

Sources & evidence

ORD record
ord-cd07c583a8a044928bba323fdf3fec8a
Source dataset
uspto-grants-2015_11
Patent number
US09193741B2

Reaction notes

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