反应详情

A solution of methyl 2-aminothiophene-3-carboxylate (3.0 g, 19.1 mmol) in formamide (95 ml) was heated at 190° C. for 4 hours. The cooled mixture was poured into water. The precipitate was filtered off, washed with water and dried. The crude product was purified by silica gel chromatography (CH2Cl2/MeOH 50:1) to yield the title compound as a white solid (1.93 g, 66%).

1. filtrationThe precipitate was filtered off
2. washwashed with water
3. customdried
4. customThe crude product was purified by silica gel chromatography (CH2Cl2/MeOH 50:1)