HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 718311Generated: October 26, 2026
3-Chloro-4-fluoroaniline → N-(3-chloro-4-fluorophenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
https://huagongshe.com/reaction/718311
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| Reactant | 4-Chloro-6-(4-fluorophenyl)thieno[2,3-d]pyrimidine | HCID 86662441 | — |
| Solvent | Tert-butyl alcohol 1,2-dichloroethane | HCID 21868497 | — |
| Product | N-(3-chloro-4-fluorophenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine | HCID 56941891 | 50% |
Reaction Steps
To a solution of 4-chloro-6-(4-fluorophenyl)thieno[2,3-d]pyrimidine (40 mg, 0.15 mmol) in 1,2-dichloroethane/t-BuOH (1:1, 1 ml) was added 3-chloro-4-fluoroaniline (22 mg, 0.15 mmol). The mixture was heated at 90° C. for 2 days. After cooling down to room temperature, the solvents were removed under reduced pressure. The crude residue was purified by silica gel chromatography (CH2Cl2/MeOH 100:1) to yield the title compound as a white solid (28 mg, 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09193741B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-e53833e1c9b14a0c9744490493b716dd |
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| Source note | uspto-grants-2015_11 |
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