4-Fluorobenzaldehyde → 2-amino-8-(4-fluorophenyl)-3,7-dihydropurin-6-one

HRID 718327Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([NH2:9])=[C:4]([NH2:10])[N:3]=1.[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=O)=[CH:14][CH:13]=1>>[NH2:1][C:2]1[N:3]=[C:4]2[C:5]([N:9]=[C:16]([C:15]3[CH:18]=[CH:19][C:12]([F:11])=[CH:13][CH:14]=3)[NH:10]2)=[C:6]([OH:8])[N:7]=1

Participants

Reactant 2

HCID 680234-Fluorobenzaldehyde

HCID 178508811HCID 178508811, compound

Product 1

HCID 1785089192-amino-8-(4-fluorophenyl)-3,7-dihydropurin-6-oneYield 60%

Procedure

This compound was synthesized from commercially available 2,5,6-triamino-4-hydroxypyrimidine (40 mmol) and 4-fluorobenzaldehyde (40 mmol), yielding the title compound in 60% yield.

Sources & evidence

ORD record: ord-d2590606043642d988f13576f3dc06eb
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09193741B2

Reaction notes

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