Potassium Acetate → HCID 123213778, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromo-2-(4-fluorophenethoxy)pyrimidine (200 mg), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (256 mg), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (24.63 mg) and KOAc (198 mg) in 1,4-dioxane (8 mL) in a sealed tube was degassed with nitrogen for 2 minutes and then heated at 85° C. for 4 hours, followed by being stirred at room temperature for 24 h. The mixture was diluted with EtOAc, washed with water, brine, dried over MgSO4 and concentrated under vacuum. The residue was purified by silica gel column (Hex/EtOAc=10:1) to give (2-(4-fluorophenethoxy)pyrimidin-5-yl)boronic acid (70 mg). LCMS (M+H)=263.1.

Provenance & Evidence