Cesium carbonate → HCID 118314222, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of (S)-ethyl 2-(5-bromo-4-(4,4-dimethylpiperidin-1-yl)-2,6-dimethylpyridin-3-yl)-2-(tert-butoxy)acetate (30 mg), (6-(4-fluorophenethoxy)pyridin-3-yl)boronic acid (18.9 mg) and Cs2CO3 (42.9 mg) in 1,4-dioxane (2 mL) and water (0.4 mL) was added Pd(PPh3)4 (7.6 mg). The mixture was flushed with nitrogen and then heated at 85° C. for 3 h. The mixture was diluted with water and then extracted with EtOAc (2×20 mL). The organic layers were combined, washed with brine and concentrated to give a residue, which was purified by the preparative HPLC to give (S)-ethyl 2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-6′-(4-fluorophenethoxy)-2,6-dimethyl-[3,3′-bipyridin]-5-yl)acetate (3.6 mg). LCMS (M+H)=592.5.

Provenance & Evidence