Sodium Hydroxide → HCID 118307794, compound

Participants

Reaction Steps

A solution of (S)-ethyl 2-(5-(3-(benzyloxy)-4-methylphenyl)-4-(4,4-dimethylpiperidin-1-yl)-2,6-dimethylpyridin-3-yl)-2-(tert-butoxy)acetate (0.0121 g, 0.021 mmol) and 1M NaOH (0.211 ml, 0.211 mmol) in EtOH (1 mL) was refluxed for 6 h. Then, cooled and purified by prep-HPLC to afford (S)-2-(5-(3-(benzyloxy)-4-methylphenyl)-4-(4,4-dimethylpiperidin-1-yl)-2,6-dimethylpyridin-3-yl)-2-(tert-butoxy)acetic acid (0.0103 g, 0.019 mmol, 90% yield) as solid and ˜3:2 mixture of isomers by H-NMR. LCMS (M+H)=545.25.

Provenance & Evidence