Toluene → HCID 86696071, compound

Participants

Reaction Steps

A mixture of compound (75) (75.0 g, 231.0 mmol) and 5%-palladium on carbon (0.5% sulfur, 50% water-containing article) (2.82 g, 3 wt %) was agitated for 18 hours under a hydrogen atmosphere in a toluene (300 mL)-IPA (100 mL) solvent. The reaction mixture was filtered and a solvent of a filtrate was distilled off by an evaporator. The residue was passed through silica gel column chromatography and recrystallized from heptane-ethanol, and thus 4-bromo-2-fluoro-1-(2-(4-propylcyclohexyl)ethyl)benzene (76) (57.1 g, yield 75.5%) was obtained.

Provenance & Evidence