HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5,5-Trimethylhexanal → (5,7,7-Trimethyloct-2-enyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5,5-Trimethylhexanal | HCID 21574 | — |
| Reactant | Phenethyltriphenylphosphonium bromide | HCID 10863251 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | (5,7,7-Trimethyloct-2-enyl)benzene | HCID 86702771 | 65.2% |
Reaction Steps
Starting from phenethyltriphenylphosphonium bromide (2.80 g, 6.26 mmol, 1.0 equiv.), n-BuLi (1.6 M in hexanes, 3.9 mL, 6.26 mmol, 1.0 equiv.) and 3,5,5-trimethylhexanal (1.33 g, 9.39 mmol, 1.5 equiv.), 0.94 g (65%) of the title compound as a colorless oil was obtained after purification by flash chromatography on SiO2 (cyclohexane/EtOAc 997:3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193935B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-340e9598e2b9495f8e00128b130f33e8 |
| Source note | uspto-grants-2015_11 |