反应详情

温度

25 °C

tert-Butyl(4-(4-(4-((tert-butyldimethylsilyl)oxy)-3-ethoxyphenyl)-3-methylbut-3-en-1-yl)phenoxy)dimethylsilane was dissolved in THF (30 mL), n-Bu4NF (30 mL, 30.0 mmol, 0.7 equiv., 1.0 M in THF) was added, and the mixture was stirred at 25° C. for 1 h. After addition of H2O, the aqueous layer was extracted with MTBE (2×), the combined organic phases were washed with brine, dried (MgSO4), filtered and the filtrate was concentrated. The residue was purified by flash chromatography on SiO2 (cyclohexane/EtOAc 9:1→4:1) to yield 5.87 g (48% over 2 steps) of the title compound as a light yellow oil.

1. extractionthe aqueous layer was extracted with MTBE (2×)
2. washthe combined organic phases were washed with brine
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. concentrationthe filtrate was concentrated
6. customThe residue was purified by flash chromatography on SiO2 (cyclohexane/EtOAc 9:1→4:1)