Water → 2-Ethoxy-4-(4-(4-hydroxyphenyl)-2-methylbut-1-enyl)phenol

HRID 718544Notes

Reaction equation

HRID 718544 reaction equation
C([Si]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([CH3:36])=[CH:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][Si](C(C)(C)C)(C)C)=[C:21]([O:33][CH2:34][CH3:35])[CH:20]=2)=[CH:11][CH:10]=1)(C)C)(C)(C)C.[N+](CCCC)(CCCC)(CCCC)CCCC.[F-].O>C1COCC1>[CH2:34]([O:33][C:21]1[CH:20]=[C:19]([CH:18]=[C:17]([CH3:36])[CH2:16][CH2:15][C:12]2[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=2)[CH:24]=[CH:23][C:22]=1[OH:25])[CH3:35]

Participants

5

Reactant 3

HCID 962WaterHCID 2724141Tetrabutylammonium FluorideHCID 86702783Tert-butyl(4-(4-(4-((tert-butyldimethylsilyl)oxy)-3-ethoxyphenyl)-3-methylbut-3-en-1-yl)phenoxy)dimethylsilane

Product 1

HCID 679822892-Ethoxy-4-(4-(4-hydroxyphenyl)-2-methylbut-1-enyl)phenol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
25 °C

Procedure

tert-Butyl(4-(4-(4-((tert-butyldimethylsilyl)oxy)-3-ethoxyphenyl)-3-methylbut-3-en-1-yl)phenoxy)dimethylsilane was dissolved in THF (30 mL), n-Bu4NF (30 mL, 30.0 mmol, 0.7 equiv., 1.0 M in THF) was added, and the mixture was stirred at 25° C. for 1 h. After addition of H2O, the aqueous layer was extracted with MTBE (2×), the combined organic phases were washed with brine, dried (MgSO4), filtered and the filtrate was concentrated. The residue was purified by flash chromatography on SiO2 (cyclohexane/EtOAc 9:1→4:1) to yield 5.87 g (48% over 2 steps) of the title compound as a light yellow oil.

Workup

  1. extractionthe aqueous layer was extracted with MTBE (2×)
  2. washthe combined organic phases were washed with brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated
  6. customThe residue was purified by flash chromatography on SiO2 (cyclohexane/EtOAc 9:1→4:1)

Sources & evidence

ORD record
ord-13af4e3945874477aa2e9f77ea1930f5
Source dataset
uspto-grants-2015_11
Patent number
US09193935B2

Reaction notes

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