HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 718550Generated: October 30, 2026
3,5,5-Trimethylhexanal → 2-(5.7.7-Trimethyloct-2-en-2-yl)naphthalene
https://huagongshe.com/reaction/718550
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3,5,5-Trimethylhexanal | HCID 21574 | — |
| Reactant | 1-(2-Naphthyl)ethyltriphenylphosphonium bromide | HCID 19842179 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 2-(5.7.7-Trimethyloct-2-en-2-yl)naphthalene | HCID 86702788 | 46.2% |
Reaction Steps
Starting from (1-(2-naphthyl)ethyltriphenylphosphonium bromide (2.80 g, 5.63 mmol, 1.0 equiv.), n-BuLi (1.6 M in hexanes, 3.5 mL, 5.63 mmol, 1.0 equiv.) and 3,5,5-trimethylhexanal (1.20 g, 8.44 mmol, 1.5 equiv.), and after stirring the mixture at 25° C. for 3 h, 0.73 g (46%) of the title compound as a colorless oil was obtained after purification by flash chromatography on SiO2 (cyclohexane/EtOAc 997:3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09193935B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-c8b157e8fa2a484eaa8601c93efd8daf |
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| Source note | uspto-grants-2015_11 |
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