Trifluoroacetic acid → HCID 117728324, compound

Participants

Reaction Steps

Compound 34b (347 mg, 0.627 mmol) was placed in an 8 mL vial equipped with a stir bar and then DCM (4 mL) was added and the solid dissolved. TFA (2 mL) was added dropwise and then the reaction was stirred at rt for 4 h. The solvent was removed under reduced pressure and then the residue was dissolved in DCM (10 mL) and MeOH (3 mL) and the solvent was removed under reduced pressure. The residue was triturated with MeOH (10 mL) to afford a white precipitate that was isolated by filtration. The residual solvent was removed under reduced pressure to afford the title compound 116. 1H-NMR (400 MHz, DMSO-d6) δ (ppm): 13.05 (br. s., 1H), 8.12-8.20 (m, 2H), 8.06 (d, J=8.6 Hz, 2H), 7.89 (d, J=8.1 Hz, 3H), 7.59-7.71 (m, 2H), 7.47-7.53 (m, 1H), 7.43 (d, J=8.6 Hz, 1H), 6.40 (d, J=5.6 Hz, 1H), 4.82 (s, 2H), 3.85-3.98 (m, 4H), 3.66-3.78 (m, 4H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C27H23N5O3S: 498.2 (M+H). Found: 498.4.

Provenance & Evidence