HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyanopyridine-5-boronic acid pinacol ester → 5-(8-Morpholino-2-(2-(quinolin-2-yl)ethynyl)imidazo[1,2-b]pyridazin-3-yl)picolinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyanopyridine-5-boronic acid pinacol ester | HCID 16414188 | — |
| Reactant | 4-(3-Bromo-2-(quinolin-2-ylethynyl)imidazo[1,2-b]pyridazin-8-yl)morpholine | HCID 117728374 | — |
| Product | 5-(8-Morpholino-2-(2-(quinolin-2-yl)ethynyl)imidazo[1,2-b]pyridazin-3-yl)picolinonitrile | HCID 117728357 | — |
Reaction Steps
Compound 18b (0.15 g, 0.35 mmol) was subjected to Suzuki coupling conditions with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile as described in Example 38, Step A to obtain compound 39a as a yellow solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C22H19N2O: 458.2 (M+H). Found: 458.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-298d9c22af7a4ae7922d0a4c80e9e41f |
| Source note | uspto-grants-2015_11 |