Diisopropylethylamine → HCID 117732499, compound

Participants

Reaction Steps

A solution of compound 41d (1.4 g, 3.4 mmol) in DMF (5 mL) was treated with 2-bromoquinoline (2.0 g, 9.6 mol), Pd(PPh3)2Cl2 (240 mg, 0.34 mmol), Cut (30 mg, 0.16 mmol) and DIPEA (4.4 g, 34.11 mmol) under N2. The reaction mixture was stirred at rt overnight, and concentrated in vacuo. The residue obtained was purified by flash column chromatography on silica gel (EtOAc:petroleum ether (1:2)) to obtain compound 41e as a yellow solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C31H34N6O3: 539.3 (M+H). found: 539.4.

Provenance & Evidence