tert-Butyl bromoacetate → HCID 117732497, compound

Participants

Reaction Steps

To a solution of compound 41f (0.15 g, 0.27 mmol) in DCM (3 mL), DIEA (54 mg, 0.42 mmol) was added. The resulting mixture was stirred for 15 min before the addition of tert-butyl 2-bromoacetate (65 mg, 0.33 mmol). The reaction mixture was stirred at rt for 2 h, and concentrated under reduced pressure. The residue obtained was purified by flash column chromatography on silica gel (ethyl acetate:petroleum ether (1:2)) to obtain compound 41g as a yellow solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C32H36N6O3: 553.3 (M+H). found: 553.1.

Provenance & Evidence