HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Bromo-2-(quinolin-2-ylethynyl)imidazo[1,2-b]pyridazin-8-yl)morpholine → (S)-tert-Butyl 3-methyl-2-(4-(8-morpholino-2-(quinolin-2-ylethynyl)imidazo[1,2-b]pyridazin-3-yl)benzamido)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Bromo-2-(quinolin-2-ylethynyl)imidazo[1,2-b]pyridazin-8-yl)morpholine | HCID 117728374 | — |
| Reactant | (S)-tert-Butyl 3-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamido)butanoate | HCID 123812944 | — |
| Product | (S)-tert-Butyl 3-methyl-2-(4-(8-morpholino-2-(quinolin-2-ylethynyl)imidazo[1,2-b]pyridazin-3-yl)benzamido)butanoate | HCID 117732500 | — |
Reaction Steps
Compound 18b was subjected to Suzuki coupling conditions with compound 43a as described in Example 38, Step A to obtain compound 43b as a yellow solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C32H38N6O4: 631.3 (M+H). Found: 631.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-b65b542d3df940708e2f91c23990ec91 |
| Source note | uspto-grants-2015_11 |