HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyanopyridine-5-boronic acid pinacol ester → 5-(8-Morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-b]pyridazin-3-yl)picolinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyanopyridine-5-boronic acid pinacol ester | HCID 16414188 | — |
| Reactant | 2-[2-[3-Bromo-8-(4-morpholinyl)imidazo[1,2-b]pyridazin-2-yl]ethyl]quinoline | HCID 117728694 | — |
| Product | 5-(8-Morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-b]pyridazin-3-yl)picolinonitrile | HCID 117728569 | — |
Reaction Steps
Compound 46a (0.5 g, 1.1 mmol) was subjected to Suzuki coupling conditions with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile as described in Example 38, Step A, to obtain compound 46b as a yellow solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C27H23N7O: 462.2 (M+H). Found: 462.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-181ea31effc741d3b260cf2d77a1b50b |
| Source note | uspto-grants-2015_11 |