4-Bromophenylhydrazine hydrochloride → HCID 19692579, compound

HRID 718649Notes

Reaction equation

HRID 718649 reaction equation
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.[O:11]([C:13]#[N:14])[K]>O>[Br:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH:10][C:13]([NH2:14])=[O:11])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 121574-Bromophenylhydrazine hydrochlorideHCID 178418250HCID 178418250, compound

Product 1

HCID 19692579HCID 19692579, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1-(4-bromophenyl)hydrazine hydrochloride (25 g, 110 mmol) and KOCN (0.73 g, 9.0 mmol) in water (500 mL) was stirred overnight at 40° C., and allowed to cool to rt. The solids formed were collected by filtration to obtain compound 52a as a grey solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C7H8BrN3O: 230.0 (M+H). Found 230.2.

Workup

  1. customThe solids formed
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-8345a0375ec349aab51e96963f492ecd
Source dataset
uspto-grants-2015_11
Patent number
US09193736B2

Reaction notes

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