Ethyl orthoformate → 1-(4-Bromophenyl)-1,2-dihydro-3H-1,2,4-triazol-3-one

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Reaction Steps

A solution of compound 52a (10 g, 43 mmol) and triethoxymethane (300 mL) was stirred at 120° C. for 2 h and allowed to cool to rt. The solids were collected by filtration and washed with Et2O (2×50 mL) to obtain compound 52b as a grey solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C8H6BrN3O: 240.0 (M+H). Found 240.2.

Provenance & Evidence