HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-[3-Bromo-8-(4-morpholinyl)imidazo[1,2-b]pyridazin-2-yl]ethyl]quinoline → 1-(4-(8-Morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-b]pyridazin-3-yl)phenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-1,2-dihydro-1,2,4-triazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-[3-Bromo-8-(4-morpholinyl)imidazo[1,2-b]pyridazin-2-yl]ethyl]quinoline | HCID 117728694 | — |
| Reactant | 1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-[[2-(trimethylsilyl)ethoxy]methyl]-2,3-dihydro-1H-1,2,4-triazol-3-one | HCID 123578271 | — |
| Product | 1-(4-(8-Morpholino-2-(2-(quinolin-2-yl)ethyl)imidazo[1,2-b]pyridazin-3-yl)phenyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-1,2-dihydro-1,2,4-triazol-3-one | HCID 123144943 | — |
Reaction Steps
Compound 46a was subjected to Suzuki coupling conditions with compound 52d using the procedures described in Example 38, step A, to obtain compound 52e as a white solid. Mass Spectrum (LCMS, ESI pos.) Calcd. For C34H39N9O3Si: 649.3 (M+H). Found 649.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-a9150812108844829d63f049b008040e |
| Source note | uspto-grants-2015_11 |