Lithium Hydroxide → (E)-3-(5-(8-Morpholino-2-(2-(quinolin-2-yl)vinyl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)propanoic acid

Participants

Reaction Steps

Compound 57d (0.58 g, 1.1 mmol) was hydrolyzed with LiOH using the procedure described in Example 54, Step E. The title compound 125 was obtained as a yellow solid. 1H-NMR (300 MHz, CD3OD) δ (ppm): 8.81 (d, J=1.5 Hz, 1H), 8.30 (d, J=8.4 Hz, 1H), 8.16 (dd, J=8.1, 2.1 Hz, 1H), 8.09 (d, J=5.7 Hz, 1H), 8.00 (t, J=8.4 Hz, 1H), 7.92-7.87 (m, 3H), 7.80-7.73 (m, 2H), 7.63-7.54 (m, 2H), 6.40 (d, J=5.7 Hz, 1H), 4.13-4.10 (m, 4H), 4.00-3.97 (m, 4H), 3.23 (t, J=7.5 Hz, 2H), 2.71 (t, J=7.5 Hz, 2H). Mass Spectrum (LCMS, ESI pos.): Calcd. for C29H26N6O3: 507.2 (M+H). Found: 507.1.

Provenance & Evidence