HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxycarbonylphenylboronic acid → Methyl 4-(2-formyl-8-morpholinoimidazo[1,2-b]pyridazin-3-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxycarbonylphenylboronic acid | HCID 2734369 | — |
| Reactant | 3-Bromo-8-morpholinoimidazo[1,2-b]pyridazine-2-carbaldehyde | HCID 117728834 | — |
| Product | Methyl 4-(2-formyl-8-morpholinoimidazo[1,2-b]pyridazin-3-yl)benzoate | HCID 117728372 | — |
Reaction Steps
Compound 14b (3.0 g, 11 mmol) was subjected to Suzuki coupling conditions with [4-(methoxycarbonyl)phenyl]boronic acid using the procedure described in Example 38, Step A to obtain compound 58c as a gray solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C19H18N4O4: 367.1 (M+H). Found: 367.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-a43e43698fc74f23b940789a07fed5b7 |
| Source note | uspto-grants-2015_11 |