2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 131734181, compound

HRID 718672Notes

Reaction equation

HRID 718672 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[O:13])[NH:11][N:12]=2)=[C:4]([F:14])[CH:3]=1.[CH3:15][Si:16]([CH2:19][CH2:20][O:21][CH2:22]Cl)([CH3:18])[CH3:17]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:22][O:21][CH2:20][CH2:19][Si:16]([CH3:18])([CH3:17])[CH3:15])[C:10](=[O:13])[N:11]([CH2:22][O:21][CH2:20][CH2:19][Si:16]([CH3:18])([CH3:17])[CH3:15])[N:12]=2)=[C:4]([F:14])[CH:3]=1

Participants

3

Reactant 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 136942077HCID 136942077, compound

Product 1

HCID 131734181HCID 131734181, compound

Procedure

Compound 59b (0.26 g, 1.0 mmol) was treated with SEMCl using the procedure described in Example 51, Step C to obtain compound 59c as a yellow oil. Mass Spectrum (LCMS, ESI pos.): Calcd. for C20H33BrFN3O3Si2: 518.1 (M+H). Found: 518.1.

Sources & evidence

ORD record
ord-94611bfc608840bcaccc334962550a4d
Source dataset
uspto-grants-2015_11
Patent number
US09193736B2

Reaction notes

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