反应详情

To compound 73g (31.3 mg, 0.061 mmol) in MeOH (0.6 mL) was added NaOMe (0.12 mL, 0.061 mmol). The resulting mixture was stirred for 30 min and the solvent was removed in vacuo to obtain a solid which was then dried at 70° C. under high vacuum to afford the title compound 140 as a white solid. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 9.47 (d, J=8.8 Hz, 1H), 8.89 (s, 1H), 8.74 (d, J=3.9 Hz, 1H), 8.15 (d, J=7.6 Hz, 1H), 7.53-7.87 (m, 7H), 6.57 (s, 1H), 4.22 (br. s., 4H), 3.86 (br. s., 4H). Mass spectrum (LCMS, ESI pos.) Calcd. For C27H21ClN6O3: 513.1 (M+H). Found 512.8.

1. customthe solvent was removed in vacuo
2. customto obtain a solid which
3. customwas then dried at 70° C. under high vacuum