Iodobenzene → 8-Morpholino-3-phenylimidazo[1,2-b]pyridazine-2-carbaldehyde

Participants

Reaction Steps

Compound 5e (300 mg, 1.3 mmol) was coupled with iodobenzene (0.21 mL, 1.9 mmol) according to the procedures described in Example 20, Step A to afford compound 74a. 1H NMR (400 MHz, CDCl3) δ (ppm): 10.11 (s, 1H), 8.09 (d, J=5.6 Hz, 1H), 7.73 (d, J=8.1 Hz, 2H), 7.44-7.63 (m, 3H), 6.13 (d, J=5.6 Hz, 1H), 4.04-4.16 (m, 4H), 3.80-4.02 (m, 4H).

Provenance & Evidence