Benzonitrile, 4-bromo- → 4-(2-Formyl-8-morpholinoimidazo[1,2-b]pyridazin-3-yl)benzonitrile

Participants

Role	Name	HCID	Charge
Reactant	Benzonitrile, 4-bromo-	HCID 12162	—
Reactant	8-Morpholinoimidazo[1,2-b]pyridazine-2-carbaldehyde	HCID 117728638	—
Product	4-(2-Formyl-8-morpholinoimidazo[1,2-b]pyridazin-3-yl)benzonitrile	HCID 117728445	—

Reaction Steps

Compound 5e (162 mg, 0.698 mmol) was coupled with 4-bromobenzonitrile (190 mg, 1.04 mmol) using the procedures described in Example 20, Step A to afford compound 76a. Mass spectrum (LCMS, ESI pos.) Calcd. For C18H15N5O2: 334.1 (M+H). found 334.1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09193736B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-0253c44f97fd40a4b8482d656312a389
Source note	uspto-grants-2015_11