HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Formyl-8-morpholinoimidazo[1,2-b]pyridazin-3-yl)benzonitrile → (E)-2-(2-(3-(4-cyanophenyl)-8-morpholinoimidazo[1,2-b]pyridazin-2-yl)vinyl)quinoline-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Formyl-8-morpholinoimidazo[1,2-b]pyridazin-3-yl)benzonitrile | HCID 117728445 | — |
| Reactant | Ethyl 2-[(diethoxyphosphinyl)methyl]-5-quinolinecarboxylate | HCID 117732530 | — |
| Product | (E)-2-(2-(3-(4-cyanophenyl)-8-morpholinoimidazo[1,2-b]pyridazin-2-yl)vinyl)quinoline-5-carboxylic acid | HCID 117728654 | — |
Reaction Steps
Compound 73d (55.0 mg, 0.165 mmol) was reacted under Horner-Emmons coupling conditions with compound 76a (58.0 mg, 0.165 mmol) using the procedures described in Example 74, Step B to afford compound 76b. Mass spectrum (LCMS, ESI pos.) Calcd. For C29H22N6O3: 503.2 (M+H). found 503.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-81f371c2fc924923b3bf6fc123c23adf |
| Source note | uspto-grants-2015_11 |