Sodium Methoxide → (E)-2-(2-(3-(4-cyanophenyl)-8-morpholinoimidazo[1,2-b]pyridazin-2-yl)vinyl)quinoline-5-carboxylic acid sodium salt

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Reaction Steps

Compound 76b (28.2 mg, 0.056 mmol) was treated with NaOMe (0.11 mL, 0.056 mmol) using the procedures described in Example 73, Step H to obtain the title compound 148. 1H NMR (400 MHz, CD3OD): δ (ppm) 9.02 (d, J=9.1 Hz, 1H), 8.07 (d, J=5.6 Hz, 1H), 7.89-8.02 (m, 6H), 7.79-7.88 (m, 3H), 7.65-7.74 (m, 1H), 6.39 (d, J=6.0 Hz, 1H), 4.08-4.13 (m, 4H), 3.92-4.00 (m, 4H). Mass spectrum (LCMS, ESI pos.) Calcd. For C29H22N6O3: 503.2 (M+H). found 503.2.

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