Sodium Methoxide → (E)-2-(2-(3-(3-methoxyphenyl)-8-morpholinoimidazo[1,2-b]pyridazin-2-yl)vinyl)quinoline-5-carboxylic acid sodium salt

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Reaction Steps

Compound 77b (28 mg, 0.055 mmol) was treated with NaOMe (0.11 mL, 0.055 mmol) using the procedures described in Example 73, Step H to afford the title compound 149. 1H NMR (400 MHz, CD3OD) δ (ppm): 8.99 (d, J=9.1 Hz, 1H), 7.92-8.04 (m, 3H), 7.87 (d, J=7.6 Hz, 1H), 7.59-7.79 (m, 3H), 7.49 (t, J=8.1 Hz, 1H), 7.22-7.35 (m, 2H), 7.08 (dd, J=7.8, 2.3 Hz, 1H), 6.23 (d, 1H), 4.07-4.12 (m, 4H), 3.93-3.99 (m, 4H), 3.88 (s, 3H). Mass spectrum (LCMS, ESI pos.) Calcd. For C29H25N5O4 508.2 (M+H). found 508.3.

Provenance & Evidence