反应详情

Compound 79d (33 mg, 0.081 mmol) was coupled with tert-butyl 4-bromobenzoate (29 μL, 0.12 mmol) using the procedure described in Example 20, Step A to afford title compound 146. 1H NMR (400 MHz, CD3OD) δ (ppm): 7.93-8.08 (m, 4H), 7.72-7.85 (m, 3H), 7.66 (t, J=7.6 Hz, 1H), 7.41-7.50 (m, 1H), 7.24-7.31 (m, 1H), 6.12 (s, 1H), 4.05 (br. s., 4H), 3.95 (d, J=3.9 Hz, 4H), 2.80-2.93 (m, 2H), 1.87-2.00 (m, 2H), 1.58 (s, 9H) Mass Spectrum (LCMS, ESI pos.): Calcd. for C33H32ClN5O3: 582.2 (M+H). found: 582.2.