HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-bromo-2-fluorobenzoate → tert-butyl 4-(6-chloro-8-morpholino-2-((1R,2S)-2-(quinolin-2-yl)cyclopropyl)imidazo[1,2-b]pyridazin-3-yl)-2-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-bromo-2-fluorobenzoate | HCID 46738774 | — |
| Reactant | 4-(6-Chloro-2-((1R,2S)-2-(quinolin-2-yl)cyclopropyl)imidazo[1,2-b]pyridazin-8-yl)morpholine | HCID 117728491 | — |
| Product | tert-butyl 4-(6-chloro-8-morpholino-2-((1R,2S)-2-(quinolin-2-yl)cyclopropyl)imidazo[1,2-b]pyridazin-3-yl)-2-fluorobenzoate | HCID 117728451 | — |
Reaction Steps
Compound 79d (100 mg, 0.246 mmol) was coupled with tert-butyl 4-bromo-2-fluorobenzoate (102 mg, 0.370 mmol) using the procedures described in Example 20, Step A to afford compound 81a. Mass Spectrum (LCMS, ESI pos.): Calcd. for C33H31ClFN5O3: 600.2 (M+H). found: 600.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-b3c9682e89874e16a4cb94c3ee8391cc |
| Source note | uspto-grants-2015_11 |