HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-(4-bromophenyl)acetate → Methyl 2-(4-(6-chloro-8-morpholino-2-((1R,25)-2-(quinolin-2-yl)cyclopropyl)imidazo[1,2-b]pyridazin-3-yl)phenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-(4-bromophenyl)acetate | HCID 316783 | — |
| Reactant | 4-(6-Chloro-2-((1R,2S)-2-(quinolin-2-yl)cyclopropyl)imidazo[1,2-b]pyridazin-8-yl)morpholine | HCID 117728491 | — |
| Product | Methyl 2-(4-(6-chloro-8-morpholino-2-((1R,25)-2-(quinolin-2-yl)cyclopropyl)imidazo[1,2-b]pyridazin-3-yl)phenyl)acetate | HCID 131734184 | — |
Reaction Steps
Compound 79d (60 mg, 0.14 mmol) was coupled with methyl 2-(4-bromophenyl)acetate (46 μL, 0.22 mmol) using the procedures described in Example 20, Step A to afford compound 82a. Mass Spectrum (LCMS, ESI pos.): Calcd. for C31H28ClN5O3: 554.2 (M+H). found: 544.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-bbddaa1ebb5b4812bbfe186a1b272673 |
| Source note | uspto-grants-2015_11 |