Sodium Methoxide → 2-(4-(6-Chloro-8-morpholino-2-((1R,25)-2-(quinolin-2-yl)cyclopropyl)imidazo[1,2-b]pyridazin-3-yl)phenyl)acetate sodium salt

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Reaction Steps

Compound 82a (30 mg, 0.054 mmol) was treated with NaOMe (36 μL, 0.10 mmol) using the procedures described in Example 73, Step H to afford title compound 173. 1H NMR (400 MHz, CD3OD) δ (ppm): 8.18 (d, J=8.6 Hz, 1H), 7.92 (d, J=8.1 Hz, 1H), 7.84 (d, J=8.1 Hz, 1H), 7.68 (t, J=7.6 Hz, 1H), 7.56 (d, J=8.1 Hz, 2H), 7.49 (t, J=6.8 Hz, 1H), 7.36 (d, J=8.6 Hz, 2H), 7.32 (d, J=8.6 Hz, 1H), 6.34 (s, 1H), 4.02-4.11 (m, 4H), 3.85-3.95 (m, 4H), 3.49 (s, 2H), 2.79-2.89 (m, 1H), 2.68-2.79 (m, 1H), 1.84-1.94 (m, 2H). Mass Spectrum (LCMS, ESI pos.): Calcd. for C30H26ClN5O3: 540.1 (M+H). found: 539.8.

Provenance & Evidence