2-Chloroquinoline → 2-((3-Bromo-8-morpholinoimidazo[1,2-b]pyridazin-2-yl)methoxy)quinoline

Participants

Reaction Conditions

Reaction Steps

To a solution of compound 83a (1 g, 3 mmol) and 2-chloroquinoline (780 mg, 4.76 mmol) in N,N-dimethylformamide (20 mL), 60% sodium hydride (200 mg, 5.00 mmol) was added in portions. The reaction mixture was stirred overnight at 80° C. and quenched by the addition of 20 mL of water. The solids were collected by filtration to afford compound 83b as a white solid. Mass Spectrum (LCMS, ESI pos.) Calcd. For C20H18BrN5O2: 440.1 (M+H). Found 440.2.

Provenance & Evidence